Rattus norvegicus is a brown lab rat also known as the Norway rat.
It is also the first mammalian species that was utilised for scientific research, hence is the most extensively used model animal in research.
It is a convenient model organism due to its smaller size, rapid life cycle, similarity to humans and they are relatively affordable. There are also a large number of mutants available and you can even manipulate the genome.
They have been used for a vast array of research including ageing, addiction, cancer, genomics, cardiovascular diseases and many more.
The first known research done in Rattus norvegicus was in America in 1908 by Elmer McCollun Day, they originally used them for trials for basic nutrition. A further experiment took place the determine protein digestion by Thomas Burr Osbourne.
- ↑ DNA Learning Centre. Rat (Rattus norvegicus). [Cited 22/10/2018]. Available from: https://www.dnalc.org/view/1717-Rat-Rattus-norvegicus-.html
- ↑ Genome Research. Functional Genomics and Rat Models. [Cited 22/10/18]; Available at: https://genome.cshlp.org/content/9/11/1013.full.html
- ↑ Day, Harry G. (1974). "Elmer Verner McCollum". Biographical Memoirs. National Academy of Sciences (U.S.). 45: 291. PMID 11615648