Renin-Angiotensin System

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The Renin-Angiotensin system (RAS), also Renin-Angiotensin-Aldosterone system, is one of the mechanisms used by the body to regulate [[blood pressure|blood pressure]]. It comes into play when the [[blood pressure|blood pressure]] is too low, in disease it can happen when the [[blood pressure|blood pressure]] is not low which can lead to [[hypertension|hypertension]].   
 
The Renin-Angiotensin system (RAS), also Renin-Angiotensin-Aldosterone system, is one of the mechanisms used by the body to regulate [[blood pressure|blood pressure]]. It comes into play when the [[blood pressure|blood pressure]] is too low, in disease it can happen when the [[blood pressure|blood pressure]] is not low which can lead to [[hypertension|hypertension]].   
  
=== <u>Mechanism</u>  ===
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== <u></u>Mechanism<u></u>  ==
  
Low [[blood pressure|blood pressure]] is detected by the juxtaglomerular apparatus&nbsp;which&nbsp;secretes&nbsp;renin. This&nbsp;[[Enzyme|enzyme]] hydrolyses&nbsp;angiotensinogen&nbsp;in the blood stream to [[angiotensin I|angiotensin I]]. Angiotensin&nbsp;I is further processed; [[angiotensin-converting-enzyme|angiotensin-converting-enzyme]] (ACE), released from the lungs, cleaves further [[Amino acids|amino acids]]&nbsp;from the protein resulting in [[angiotensin II|angiotensin II]]. This [[protein|protein]] help the body to raise the [[blood pressure|blood pressure]] by many mechanisms including [[vasoconstriction|vasoconstriction]], [[ADH|ADH]] secretion and [[aldosterone|aldosterone]] secretion.
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Low [[Blood pressure|blood pressure]] is detected by the juxtaglomerular apparatus&nbsp;which&nbsp;secretes&nbsp;renin. This&nbsp;[[Enzyme|enzyme]] hydrolyses&nbsp;angiotensinogen&nbsp;in the blood stream to [[Angiotensin I|angiotensin I]]. Angiotensin&nbsp;I is further processed; [[Angiotensin-converting-enzyme|angiotensin-converting-enzyme]] (ACE), released from the lungs, cleaves further [[Amino acids|amino acids]]&nbsp;from the protein resulting in [[Angiotensin II|angiotensin II]]. This [[Protein|protein]] help the body to raise the [[Blood pressure|blood pressure]] by many mechanisms including [[Vasoconstriction|vasoconstriction]], [[ADH|ADH]] secretion and [[Aldosterone|aldosterone]] secretion.

Revision as of 13:56, 15 November 2010

The Renin-Angiotensin system (RAS), also Renin-Angiotensin-Aldosterone system, is one of the mechanisms used by the body to regulate blood pressure. It comes into play when the blood pressure is too low, in disease it can happen when the blood pressure is not low which can lead to hypertension

Mechanism

Low blood pressure is detected by the juxtaglomerular apparatus which secretes renin. This enzyme hydrolyses angiotensinogen in the blood stream to angiotensin I. Angiotensin I is further processed; angiotensin-converting-enzyme (ACE), released from the lungs, cleaves further amino acids from the protein resulting in angiotensin II. This protein help the body to raise the blood pressure by many mechanisms including vasoconstriction, ADH secretion and aldosterone secretion.

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