Retinoblastoma protein (pRb) is a tumour suppressor protein which acts as a cell cycle checkpoint at G1 phase. pRb prevents progression of damaged cells from G1 phase to S phase of cell cycle to disable abnormal cell replication which might develop benign or malignant tumour. By binding to and inactivating the transcription factors that allow cells entering S phase, pRb can suppress cell replication and keep the target cell in G1 phase.
- ↑ Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH (November 1991). "The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle". Cell. 67 (2): 293–302
- ↑ Emmi Rotgers1, Mirja Nurmio1, Sheyla Cisneros-Montalvo and Jorma Toppari1fckLRUniversity of Turku, Turku, Finland (April 2, 2016)Endocrine Society's 98th Annual Meeting and Expo, April 1–4, 2016 - BostonfckLRLBSat-11:fckLRRetinoblastoma Protein Negatively Regulates E2F3 Transcription Factor to Maintain Adult Sertoli Cell Quiescence
- ↑ de Jager SM, Maughan S, Dewitte W, Scofield S, Murray JA (June 2005). "The developmental context of cell-cycle control in plants". Semin. Cell Dev. Biol. 16 (3): 385–96