Retinoblastoma protein

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Retinoblastoma protein (pRb) is a tumour suppressor protein which acts as a cell cycle checkpoint at G1 phase. pRb prevents progression of damaged cells from G1 phase to S phase of the cell cycle to disable abnormal cell replication which might develop a benign or malignant tumour[1][2]. By binding to and inactivating the transcription factors that allow cells entering S phase, pRb can suppress cell replication and keep the target cell in G1 phase[3].


  1. Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH (November 1991). "The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle". Cell. 67 (2): 293–302
  2. Emmi Rotgers1, Mirja Nurmio1, Sheyla Cisneros-Montalvo and Jorma Toppari1 University of Turku, Turku, Finland (April 2, 2016)Endocrine Society's 98th Annual Meeting and Expo, April 1–4, 2016 - Boston LBSat-11: Retinoblastoma Protein Negatively Regulates E2F3 Transcription Factor to Maintain Adult Sertoli Cell Quiescence
  3. de Jager SM, Maughan S, Dewitte W, Scofield S, Murray JA (June 2005). "The developmental context of cell-cycle control in plants". Semin. Cell Dev. Biol. 16 (3): 385–96
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