Rho dependent termination
RNA polymerase stops transcribing DNA into RNA at terminator sequences. Rho dependent termation is one of the two types of termination. Rho factor is a helicase composed of six identical subunits, which unwinds RNA-DNA and RNA-RNA duplexes. This unwinding is powered by the hydrolysis of nucleoside triphosphates. The Rho factor binds to RNA and unzips DNA, weakening the contact between the RNA and DNA strands in the RNA-DNA duplexes, causing dissociation to become more favourable.