Salmeterol

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 Salmeterol

Salmeterol is an oral drug that is inhaled to control the symptoms of asthma, a chronic obstructive pulmonary disease (COPD). It is classified as a B2-adrenoreceptor agonist that acts to dilate the airway smooth muscle through bronchodilation.

Unlike Salbutamol that has a mechanism of action that lasts between 4 and 6 hours, Salmeterol can last up to 12 hours and has a half life of 5.5 hours before it is metabolised by CYP3A4 by hydroxylation and removed by the body. The mechanism of action is long lasting due to the fact the drug has a high B2-receptor affinity allowing constant activation of the active site followed by slow dissociation as it is a highly lipophilic molecule, meaning the overall effects are useful for symptom management.

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