Sequence degeneracy

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(Added more detail to the definition and an example of how to work out degeneracy from a protein sequence)
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Sequence Degeneracy occurs as a result of back translating a [[Protein sequence|protein sequence]] into a [[DNA sequence|DNA sequence]].&nbsp;<br><br>Degeneracy occurs when back&nbsp;translating a [[Protein sequence|protein sequence]] due to the many different combinations of bases that can create the same [[Amino acid|amino acid]] sequnce.&nbsp;<br>However [[DNA sequences|DNA sequences]] with ambiguous bases can be accounted for using the [[IUB|IUB]] and [[IUB Complement|complement code]] to work out the correct [[Reverse translation|reverse translation]].&nbsp;<br>For example, the protein sequence 'SCIENCE' contains the [[Amino acids|amino acids]]:&nbsp;Serine, Cysteine, Isoleucine, Glutamic, Asparagine, Cysteine and Glutamic respectively, <br>however as each of these amino acids can be encoded by more than one t[[Triplet code|riplet]], ambiguity arises. <br><br>In this instance:&nbsp;'SCIENCE'<br>Serine = 6 possible codons&nbsp;<br>Cysteine = 2 possible codons&nbsp; &nbsp;<br>Isoleucine = 3 possible codons<br>Glutamic = 2 possible codons&nbsp; &nbsp; <br>Asparagine = 2 possible codons&nbsp; &nbsp; <br>Cysteine = 2 possible codons<br>Glutamic = 2 possible codons&nbsp;<br><br>The degeneracy of the sequence can be determined through the multpiplication of the number of possible&nbsp;[[Codons|codons]] at each amino acid on the sequence.&nbsp;<br>Degeneracy in this case is:&nbsp;6 x 2 x 3 x 2 x 2 x 2 x 2 = 576&nbsp;<br><br>
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Sequence Degeneracy occurs as a result of back translating a [[Protein sequence|protein sequence]] into a [[DNA sequence|DNA sequence]].  
  
Bioinformatica.upf.edu. (2018). SNPs in Human Selenoproteins Genes. [online] Available at:[[Javascript:void(0);/*1540564120009*/|http://bioinformatica.upf.edu/2005/projectes05/3.2.4/material.html&nbsp;]]<br>
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Degeneracy occurs when back translating a [[Protein sequence|protein sequence]] due to the many different combinations of bases that can create the same [[Amino acid|amino acid]] sequence.
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However [[DNA sequences|DNA sequences]] with ambiguous bases can be accounted for using the [[IUB|IUB]] and [[IUB Complement|complement code]] to work out the correct [[Reverse translation|reverse translation]].
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The protein sequence 'SCIENCE' contains the [[Amino acids|amino acids]]: Serine, Cysteine, Isoleucine, Glutamic, Asparagine, Cysteine and Glutamic respectively, however as each of these amino acids can be encoded by more than one t[[Triplet code|riplet]], ambiguity arises.
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In this instance: 'SCIENCE'
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*[[Serine|Serine]] = 6 possible codons
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*[[Cysteine|Cysteine]] = 2 possible codons
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*[[Isoleucine|Isoleucine]] = 3 possible codons
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*[[Glutamic|Glutamic]] = 2 possible codons
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*[[Asparagine|Asparagine]] = 2 possible codons
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*[[Cysteine|Cysteine]] = 2 possible codons
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*[[Glutamic|Glutamic]] = 2 possible codons
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The degeneracy of the sequence can be determined through the multiplication of the number of possible [[Codons|codons]] at each amino acid on the sequence<ref>Bioinformatica.upf.edu. (2005). SNPs in Human Selenoproteins Genes. [online] Available at: http://bioinformatica.upf.edu/2005/projectes05/3.2.4/material.html [Last accessed 31 Oct. 2018].</ref>.
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Degeneracy in this case is: 6 x 2 x 3 x 2 x 2 x 2 x 2 = 576<br>
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=== References ===
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<references /><br>

Latest revision as of 11:15, 5 November 2018

Sequence Degeneracy occurs as a result of back translating a protein sequence into a DNA sequence.

Degeneracy occurs when back translating a protein sequence due to the many different combinations of bases that can create the same amino acid sequence.

However DNA sequences with ambiguous bases can be accounted for using the IUB and complement code to work out the correct reverse translation.

The protein sequence 'SCIENCE' contains the amino acids: Serine, Cysteine, Isoleucine, Glutamic, Asparagine, Cysteine and Glutamic respectively, however as each of these amino acids can be encoded by more than one triplet, ambiguity arises.

In this instance: 'SCIENCE'

The degeneracy of the sequence can be determined through the multiplication of the number of possible codons at each amino acid on the sequence[1].

Degeneracy in this case is: 6 x 2 x 3 x 2 x 2 x 2 x 2 = 576

References

  1. Bioinformatica.upf.edu. (2005). SNPs in Human Selenoproteins Genes. [online] Available at: http://bioinformatica.upf.edu/2005/projectes05/3.2.4/material.html [Last accessed 31 Oct. 2018].

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