Sequence degeneracy

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Sequence Degeneracy occurs as a result of back translating a protein sequence into a DNA sequence.

Degeneracy occurs when back translating a protein sequence due to the many different combinations of bases that can create the same amino acid sequence.

However DNA sequences with ambiguous bases can be accounted for using the IUB and complement code to work out the correct reverse translation.

The protein sequence 'SCIENCE' contains the amino acids: Serine, Cysteine, Isoleucine, Glutamic, Asparagine, Cysteine and Glutamic respectively, however as each of these amino acids can be encoded by more than one triplet, ambiguity arises.

In this instance: 'SCIENCE'

The degeneracy of the sequence can be determined through the multiplication of the number of possible codons at each amino acid on the sequence.

Degeneracy in this case is: 6 x 2 x 3 x 2 x 2 x 2 x 2 = 576 (2018). SNPs in Human Selenoproteins Genes. [online] Available at:

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