Sex chromosome

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Sex is determined by the sex [[Chromosome|chromosomes]], also known as allosomes,&nbsp;of a particular organism<ref>1. Gu L, Walters J. Evolution of Sex Chromosome Dosage Compensation in Animals: A Beautiful Theory, Undermined by Facts and Bedeviled by Details. Genome Biology and Evolution. 2017;9(9):2461-2476.</ref>. In humans, females have 2 X chromosomes whilst males have XY chromosomes. The female (in humans and many other mammals) is known as the [[Homogametic|homogametic]] sex, whilst the male is known as the [[Heterogametic|heterogametic]] sex. By contrast some organisms (birds and some reptiles, butterflies and moths) the male is homogametic and the female is heterogametic. In this case the sex chromosomes are represented by WZ (female) and ZZ (male) rather than the XX-XY mechanism.<br>  
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Sex is determined by the sex [[Chromosome|chromosomes]], also referred to as allosomes,&nbsp;of a particular organism<ref>1. Gu L, Walters J. Evolution of Sex Chromosome Dosage Compensation in Animals: A Beautiful Theory, Undermined by Facts and Bedeviled by Details. Genome Biology and Evolution. 2017;9(9):2461-2476.</ref>. In humans, females have 2 X chromosomes whilst males have XY chromosomes. The female (in humans and many other mammals) is known as the [[Homogametic|homogametic]] sex, whilst the male is known as the [[Heterogametic|heterogametic]] sex. By contrast some organisms (birds and some reptiles, butterflies and moths) the male is homogametic and the female is heterogametic. In this case the sex chromosomes are represented by WZ (female) and ZZ (male) rather than the XX-XY mechanism.<br>  
  
 
There are many different disorders and diseases associted with sex chromosomes resulting from [[Non disjunction|non disjunction]] during meiosis:  
 
There are many different disorders and diseases associted with sex chromosomes resulting from [[Non disjunction|non disjunction]] during meiosis:  
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*[[Turner syndrome|Turner syndrome]] is caused by [[Monosomy|monosomy]] of the X chromosome (45,X). The affected female will probably not sexually mature properly and will oftern experience spontaneous abortion. Those affected also tend to be [[Phenotype|phenotypically]] short <ref>[Daniel L. Hartl and Elizabeth W. Jones (2009) Genetics analysis of genes and genomes (seventh edition) mississauga, Jones and Bartlett Publishers, Inc.]</ref><ref>Genetics Home Reference, (2014). Klinefelter syndrome. [online] Available at: http://ghr.nlm.nih.gov/condition/klinefelter-syndrome [Accessed 14 Nov. 2014]</ref>.
 
*[[Turner syndrome|Turner syndrome]] is caused by [[Monosomy|monosomy]] of the X chromosome (45,X). The affected female will probably not sexually mature properly and will oftern experience spontaneous abortion. Those affected also tend to be [[Phenotype|phenotypically]] short <ref>[Daniel L. Hartl and Elizabeth W. Jones (2009) Genetics analysis of genes and genomes (seventh edition) mississauga, Jones and Bartlett Publishers, Inc.]</ref><ref>Genetics Home Reference, (2014). Klinefelter syndrome. [online] Available at: http://ghr.nlm.nih.gov/condition/klinefelter-syndrome [Accessed 14 Nov. 2014]</ref>.
  
A pair of sex [[Chromosomes|chromosomes]] in a diploid organism is the only pair in which the chromosomes are not morphologically similar homologs.There are two [[Chromosome|chromosomes]] responsible for determinig sex of an organism. In most organisms these are the [[X chromosome|X]] and [[Y chromosome|Y chromosomes]].&nbsp;In humans and most other animals, females are the&nbsp;&nbsp;[[Homogametic|homogametic]]&nbsp;sex as they inherit two X chromosomes (XX), and males&nbsp;are the&nbsp;[[Heterogametic|heterogametic]]&nbsp;sex as they inherit one X chromosome and one Y chromosome (XY). However in some organisms such as birds, moths, butterflies, some reptiles and some fish,&nbsp;the opposite applies, meaning that&nbsp;the male is the homogametic sex (XX) and the female is the heterogametic sex (XY).<ref>Hartl, D. L., Ruvolo, M. (2011) pp131-136 Genetics: Analysis of Genes and Genomes, 8th ed., Burlington: Jones &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Bartlett Learning, LLC</ref>  
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A pair of sex [[Chromosomes|chromosomes]] in a diploid organism is the only pair in which the chromosomes are not morphologically similar homologs.There are two [[Chromosome|chromosomes]] responsible for determinig sex of an organism. In most organisms these are the [[X chromosome|X]] and [[Y chromosome|Y chromosomes]].&nbsp;In humans and most other animals, females are the&nbsp;&nbsp;[[Homogametic|homogametic]]&nbsp;sex as they inherit two X chromosomes (XX), and males&nbsp;are the&nbsp;[[Heterogametic|heterogametic]]&nbsp;sex as they inherit one X chromosome and one Y chromosome (XY). However in some organisms such as birds, moths, butterflies, some reptiles and some fish,&nbsp;the opposite applies, meaning that&nbsp;the male is the homogametic sex (XX) and the female is the heterogametic sex (XY).<ref>Hartl, D. L., Ruvolo, M. (2011) pp131-136 Genetics: Analysis of Genes and Genomes, 8th ed., Burlington: Jones &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Bartlett Learning, LLC</ref>  
  
The inheritance of different sex chromosomes comes about as the homogametic parent always passes on an X chromosome in their gametes and the heterogametic parent will either pass on an X chromosome (producing a homogametic embryo) or a Y chromosome (producing a heterogametic embryo). Roughly half the gametes produced by the heterogametic parent will contain an X chromosome and roughly half will contain a Y chromosome, meaning that the ratio of males to females in the offspring will be roughly 1:1.<ref>Hartl, D. L., Ruvolo, M. (2011) pp131-136 Genetics: Analysis of Genes and Genomes, 8th ed., Burlington: Jones &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Bartlett Learning, LLC</ref>  
+
The inheritance of different sex chromosomes comes about as the homogametic parent always passes on an X chromosome in their gametes and the heterogametic parent will either pass on an X chromosome (producing a homogametic embryo) or a Y chromosome (producing a heterogametic embryo). Roughly half the gametes produced by the heterogametic parent will contain an X chromosome and roughly half will contain a Y chromosome, meaning that the ratio of males to females in the offspring will be roughly 1:1.<ref>Hartl, D. L., Ruvolo, M. (2011) pp131-136 Genetics: Analysis of Genes and Genomes, 8th ed., Burlington: Jones &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Bartlett Learning, LLC</ref>  
  
 
==== References  ====
 
==== References  ====
  
 
<references /><br>
 
<references /><br>

Revision as of 13:36, 17 November 2018

Sex is determined by the sex chromosomes, also referred to as allosomes, of a particular organism[1]. In humans, females have 2 X chromosomes whilst males have XY chromosomes. The female (in humans and many other mammals) is known as the homogametic sex, whilst the male is known as the heterogametic sex. By contrast some organisms (birds and some reptiles, butterflies and moths) the male is homogametic and the female is heterogametic. In this case the sex chromosomes are represented by WZ (female) and ZZ (male) rather than the XX-XY mechanism.

There are many different disorders and diseases associted with sex chromosomes resulting from non disjunction during meiosis:

A pair of sex chromosomes in a diploid organism is the only pair in which the chromosomes are not morphologically similar homologs.There are two chromosomes responsible for determinig sex of an organism. In most organisms these are the X and Y chromosomes. In humans and most other animals, females are the  homogametic sex as they inherit two X chromosomes (XX), and males are the heterogametic sex as they inherit one X chromosome and one Y chromosome (XY). However in some organisms such as birds, moths, butterflies, some reptiles and some fish, the opposite applies, meaning that the male is the homogametic sex (XX) and the female is the heterogametic sex (XY).[4]

The inheritance of different sex chromosomes comes about as the homogametic parent always passes on an X chromosome in their gametes and the heterogametic parent will either pass on an X chromosome (producing a homogametic embryo) or a Y chromosome (producing a heterogametic embryo). Roughly half the gametes produced by the heterogametic parent will contain an X chromosome and roughly half will contain a Y chromosome, meaning that the ratio of males to females in the offspring will be roughly 1:1.[5]

References

  1. 1. Gu L, Walters J. Evolution of Sex Chromosome Dosage Compensation in Animals: A Beautiful Theory, Undermined by Facts and Bedeviled by Details. Genome Biology and Evolution. 2017;9(9):2461-2476.
  2. [Daniel L. Hartl and Elizabeth W. Jones (2009) Genetics analysis of genes and genomes (seventh edition) mississauga, Jones and Bartlett Publishers, Inc.]
  3. Genetics Home Reference, (2014). Klinefelter syndrome. [online] Available at: http://ghr.nlm.nih.gov/condition/klinefelter-syndrome [Accessed 14 Nov. 2014]
  4. Hartl, D. L., Ruvolo, M. (2011) pp131-136 Genetics: Analysis of Genes and Genomes, 8th ed., Burlington: Jones &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Bartlett Learning, LLC
  5. Hartl, D. L., Ruvolo, M. (2011) pp131-136 Genetics: Analysis of Genes and Genomes, 8th ed., Burlington: Jones &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Bartlett Learning, LLC

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