Silent mutation

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A silent mutation is a mutation in a nucleotide sequence, which does not change the sequence of amino acids. Even regions outside the coding sequence could be affected by a silent mutation. In non-coding regions in DNA, the nucleotide sequence does not have bases needed for the protein required[1].

Silent mutations do not affect the phenotype as there are no change in amino acid sequence[2].


  1. Daniel L. Hartl and Elizabeth W. Jones (2009) Genetics: Genes and Genomes, 7th Edition, London, Jones and Bartlett Publishers, pg 513
  2. November 24, 2014.

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