Steroid

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=== Steroids and intracellular receptors  ===
 
=== Steroids and intracellular receptors  ===
  
[[Steroids|Steroid hormones]] are lipids and so can enter the cell by simple diffusion across the [[Phospholipid bilayer|plasma membrane]]. The receptors for this hormone exist either in the cytoplasm or nucleus, which is where the hormone binds to them. When the hormone binds to the receptor, a  series of events occurs:
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[[Image:Nuclear Receptors.jpg|frame|643x367px|Nuclear Receptors.jpg]]
  
[[Image:Nuclear Receptors.jpg|frame|643x367px]]
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[[Steroids|Steroid hormones]] are lipids and so can enter the cell by simple diffusion across the [[Phospholipid bilayer|plasma membrane]]. The receptors for this hormone exist either in the cytoplasm or nucleus, which is where the hormone binds to them. When the hormone binds to the receptor, a  series of events occurs:
  
*The receptor is activated due to a conformational changes in the [[Neurotransmitter|receptor]] induced by the binding hormone. This activation leads to the receptor being able to bind to [[DNA|DNA]].
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*Activated receptors bind to the [[Transcription|DNA]] binding domain, which are short specific sequences of DNA which are located in promoters of hormone-responsive genes.
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*The receptor is activated due to a&nbsp;conformational changes in the [[Neurotransmitter|receptor]] induced by the binding hormone. This activation&nbsp;leads to the receptor being able to&nbsp;bind to&nbsp;[[DNA|DNA]].  
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*Activated receptors bind to the [[Transcription|DNA]] binding domain, which are short specific sequences of DNA which are located in promoters of hormone-responsive genes.  
 
*Transcription from those genes to which the receptor is bound is affected. Most commonly, receptor binding stimulates transcription.
 
*Transcription from those genes to which the receptor is bound is affected. Most commonly, receptor binding stimulates transcription.
  
The hormone-receptor complex at&nbsp;the ligand binding domain&nbsp;thus&nbsp;behaves as a [[transcription factor|transcription factor]]. Due to steroid hormone's ability to diffuse freely through the lipid bilayer due to being hydrophobic they can have a long lasting effect on a target cell and their signal and remain active from hours - days <ref>1998, Hormones with Intracellular Receptors, http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/moaction/intracell.html, 22.11.12</ref>.
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The hormone-receptor complex at&nbsp;the ligand binding domain&nbsp;thus&nbsp;behaves as a [[Transcription factor|transcription factor]]. Due to steroid hormone's ability to diffuse freely through the lipid bilayer due to being hydrophobic they can have a long lasting effect on a target cell and their signal and remain active from hours - days <ref>1998, Hormones with Intracellular Receptors, http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/moaction/intracell.html, 22.11.12</ref>.  
  
=== References ===
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=== References ===
  
<references />
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<references />  
  
 
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Revision as of 01:24, 23 November 2012

Steroids and intracellular receptors

Nuclear Receptors.jpg

Steroid hormones are lipids and so can enter the cell by simple diffusion across the plasma membrane. The receptors for this hormone exist either in the cytoplasm or nucleus, which is where the hormone binds to them. When the hormone binds to the receptor, a  series of events occurs:


The hormone-receptor complex at the ligand binding domain thus behaves as a transcription factor. Due to steroid hormone's ability to diffuse freely through the lipid bilayer due to being hydrophobic they can have a long lasting effect on a target cell and their signal and remain active from hours - days [1].

References

  1. 1998, Hormones with Intracellular Receptors, http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/moaction/intracell.html, 22.11.12


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