Steroid

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Steroids and intracellular receptors

Nuclear Receptors.jpg

Steroid hormones are lipids and so can enter the cell by simple diffusion across the plasma membrane. The receptors for this hormone exist either in the cytoplasm or nucleus, which is where the hormone binds to them. When the hormone binds to the receptor, a  series of events occurs:


The hormone-receptor complex at the ligand binding domain thus behaves as a transcription factor. Due to steroid hormone's ability to diffuse freely through the lipid bilayer due to being hydrophobic they can have a long lasting effect on a target cell and their signal and remain active from hours - days [1].

References

  1. 1998, Hormones with Intracellular Receptors, http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/moaction/intracell.html, 22.11.12


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