T cell receptors

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A T-Cell receptor is a protein molecule that can be found on the surface of T Lymphocytes (T-Cells). T-Cells are part of the immune system and are responsible for many of the immune responses that lead to allergic reactions, transplanted organ rejections and autoimmune diseases[1]. T-Cells circulate around the body and scan for abnormalities using their T receptors . When T cell receptor binds to antigen presented by the MHC class I/II molecules , signals are sent into the T cell[2].  The T-Cell receptors are heterodimers as they consist of two different protein chains. The chains are non-covalently associated with a complex of several polypeptides called CD3 antigens[3].

References

  1. http://www.tcells.org/scientific/abTCR/
  2. https://www.sciencedirect.com/science/article/pii/S0960982205004884
  3. http://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=T-Cell+Receptor

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