Tata box

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The TATA box is the 5' TATA 3' sequence which is found in the DNA strand of a promoter and is found in the core elements. The TATA box is usually found near the -31--26 region of the promoter and its sequence is T - A -T - A - A/T - A - A/T - A/G. The TATA box is a common promoter sequence recognized by RNA Polymerase II. It is found in both prokaryotes and eukaryotes however in the two it's spacing from the transcriptional start site differs. A eukaryotic cell does not have to have a TATA box and can instead have a combination of different core promoter elements, e.g. initiator element (which is basically just a pyrimidine ring). In mammals ~60-70% of protein coding genes lack the obvious TATA sequence and it is therefore transcription can occur at other start sites, such as CpG islands[1][2].

References

  1. http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks/www.bio.davidson.edu/Biology/Courses/Molbio/MolStudents/01frschnell/genbank.html
  2. https://www.ncbi.nlm.nih.gov/protein/EJG07979.1
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