Telomerase

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Telomerase is comprised of a protein and a RNA subunit. The protein is Reverse transcriptase Enzyme called TERT which uses the RNA subunit TERC as a template for the addition of Nucleotides in repeating patterns to the overhang telomere ends of chromosome on the lagging strand of DNA to allow replication to finish and the cell to continue with division. The size of the RNA subunit varies between species depending on the telomere sequence needed. For example theTetrahymena thermophila has 159 nucleotide bases in its RNA subunit, whereas budding yeast has an RNA subunit of 1167 nucleotides.

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