Transpeptidase

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&nbsp;Transpeptidase is an enzyme present in almost all bacteria. It is used to create cross-links (covalent bonds) between peptidoglycan molecules in the bacterial cell wall. Firstly, the enzyme binds to the D-Ala-D-Ala end of the peptidoglycan polysaccharide, releasing a D-Alanine residue as it does. Next, the enzyme connects an adjacent peptidoglycan to the original one using covalent bonds between the polysaccharide region of each molecule. Transpeptidase is inhibited by beta-lactam antibiotics, such as the group of penicillins.<ref>SandwalkfckLRHow Penicillin Works to Kill BacteriafckLRJune 12, 2007 [cited 19/11/2018]fckLRhttps://sandwalk.blogspot.com/2007/06/how-penicillin-works-to-kill-bacteria.html</ref>  
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Transpeptidase is an [[enzyme|enzyme]] present in almost all [[bacteria|bacteria]]. It is used to create cross-links ([[covalent bonds|covalent bonds]]) between [[peptidoglycan|peptidoglycan]] [[molecules|molecules]] in the [[bacterial cell wall|bacterial cell wall]]. Firstly, the enzyme binds to the [[D-Ala-D-Ala|D-Ala-D-Ala]] end of the peptidoglycan [[polysaccharide|polysaccharide]], releasing a D-[[Alanine|Alanine]] residue as it does. Next, the enzyme connects an adjacent peptidoglycan to the original one using covalent bonds between the polysaccharide region of each [[molecule|molecule]]. Transpeptidase is inhibited by [[beta-lactam antibiotics|beta-lactam antibiotics]], such as the group of [[penicillins|penicillins]]<ref>Sandwalk How Penicillin Works to Kill Bacteria June 12, 2007 [cited 19/11/2018] https://sandwalk.blogspot.com/2007/06/how-penicillin-works-to-kill-bacteria.html</ref>.
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=== References  ===
  
 
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Latest revision as of 13:35, 19 November 2018

Transpeptidase is an enzyme present in almost all bacteria. It is used to create cross-links (covalent bonds) between peptidoglycan molecules in the bacterial cell wall. Firstly, the enzyme binds to the D-Ala-D-Ala end of the peptidoglycan polysaccharide, releasing a D-Alanine residue as it does. Next, the enzyme connects an adjacent peptidoglycan to the original one using covalent bonds between the polysaccharide region of each molecule. Transpeptidase is inhibited by beta-lactam antibiotics, such as the group of penicillins[1].

References

  1. Sandwalk How Penicillin Works to Kill Bacteria June 12, 2007 [cited 19/11/2018] https://sandwalk.blogspot.com/2007/06/how-penicillin-works-to-kill-bacteria.html
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