Transpeptidase

From The School of Biomedical Sciences Wiki
Revision as of 13:35, 19 November 2018 by Nnjm2 (Talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search

Transpeptidase is an enzyme present in almost all bacteria. It is used to create cross-links (covalent bonds) between peptidoglycan molecules in the bacterial cell wall. Firstly, the enzyme binds to the D-Ala-D-Ala end of the peptidoglycan polysaccharide, releasing a D-Alanine residue as it does. Next, the enzyme connects an adjacent peptidoglycan to the original one using covalent bonds between the polysaccharide region of each molecule. Transpeptidase is inhibited by beta-lactam antibiotics, such as the group of penicillins[1].

References

  1. Sandwalk How Penicillin Works to Kill Bacteria June 12, 2007 [cited 19/11/2018] https://sandwalk.blogspot.com/2007/06/how-penicillin-works-to-kill-bacteria.html
Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox