Ubiquinone

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Ubiquinone is a quinone found in the lipid bilayer and involved in the respiratory electron transport chain as an electron carrier[1]. As an electron carrier ubiquinone donates or picks up electrons in redox reactions. Ubiquinone is a small hydrophobic molecule ubiquinone has the ability to move easily through the lipid bilayer and is not located in a fixed position.

Ubiquinone, also known as coenzyme Q, plays an important role in the electron transport chain in mitochondria[2]. Coenzyme Q transfers electrons from complex I and complex II to complex III in the electron transport chain and is synthesised in all eukaryotic cells. Due to the fact that ubiquinone is essential in the production of ATP, a deficiency in the cofactor can result in multiple diseases[3].

References

  1. Alberts et al (2008) Molecular Biology of the Cell, 5th edition, New York: Garland Science. Chapter 14, Page 831
  2. Sarah L Molyneux,1,* Joanna M Young,2 Christopher M Florkowski,1,2 Michael Lever,1 and Peter M George1. Coenzyme Q10: Is There a Clinical Role and a Case for Measurement? Clin Biochem Rev. 2008 May; 29(2): 71–82.
  3. Trends Biochem Sci. 2017 Oct; 42(10): 824–843. Molecular Genetics of Ubiquinone Biosynthesis in Animals. Crit Rev Biochem Mol Biol. 2013 Jan-Feb; 48(1): 69–88.
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