Uncompetitive inhibitors

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Uncompetitive inhibitors are one of three reversible enzyme inhibitors.

They are similar to a non-competitive inhibitor, as they utilise a binding site away from the enzyme active site, but uncompetitive inhibitors only bind to an enzyme-substrate complex[1], rather than free enzymes.

Effect on Vmax and Km

Uncompetitive inhibitors decrease both Vmax and Km[2].
The Vmax decreases as the inhibitor prevents the enzyme-substrate complex from completing the reaction and releasing products.
Km decreases due to the enzyme-substrate complex being unable to dissociate, which increases the enzyme's affinity for the substrate.


  1. V.Leskovac. Comprehensive enzyme kinetics. New York:Kluwer academic/Plenum Publishers,2003
  2. T.Palmer,P.L.Bonner.Enzymes:Biochemistry,biotechnology,clinical chemistry.2nd.Elsevier science & technology,2007

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