Uncompetitive inhibitors

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Uncompetitive inhibitors are one of three reversible enzyme inhibitors.

They are similar to a non-competitive inhibitor, as they utilise a binding site away from the enzyme active site, but uncompetitive inhibitors only bind to an enzyme-substrate complex[1], rather than free enzymes.

Effect on Vmax and Km

Uncompetitive inhibitors decrease both Vmax and Km[2].
The Vmax decreases as the inhibitor prevents the enzyme-substrate complex from completing the reaction and releasing products.
Km decreases due to the enzyme-substrate complex being unable to dissociate, which increases the enzyme's affinity for the substrate.


  1. V.Leskovac,(2003) Comprehensive enzyme kinetics. New York:Kluwer academic/Plenum Publishers
  2. T.Palmer,P.L.Bonner,(2007) Enzymes:Biochemistry,biotechnology,clinical chemistry, 2nd edition. Elsevier science and technology

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