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A uniporter is a facilitated diffusion channel that transports only one solute across a cell membrane at any given time. The molecule moves down its concentration gradient e.g glucose and it does not require energy in the form of ATP to carry out it's function. Uniporter proteins undergo a conformational change in order to allow the substrate to pass through[1].  

The glucose transporter GLUT is an exmple of a uniporter protein, these uniporters allow glucose to cross the cell membrane, which normally it would be unable to do as glucose is a molecule that is too large to simply diffuse across the lipid bilayer[2].


  1. H. Lodish. Molecular Cell Biology. 6th Ed, New York: W. H Freeman and Company. 2008.
  2. J. Hardin. Becker's World of the Cell. 8th Ed. San Francisco: Pearson. 2012.

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