Vesicles are intracellular transporters, used to move macromolecules around the cell. A vesicle is made when an invaginated membrane part buds off from an organelle. This organelle is usually the the Golgi Apparatus; vesicles bud from the 'trans' end. Vesicles are vital to processes of intracellular transport, such as endo- and exocytosis. Vesicles have the ability to release or expel thier contents on reaching and fusing to the plasma membrane. For example, vesicles transport acetylcholine to the pre-synaptic membrane of a neuronal cell, where it is released into the synaptic cleft, to be received at the post-synaptic membrane. Vesicles are coated in protein. Different protein coats aid different transport steps. Among the great variety of protein coats is Clathrin. A vesicle's Clathrin coat can partly determine its destination, as the coat influences the selection of molecules for transport. A vesicle's destination is also influenced by two other proteins, Rab proteins and SNAREs. Rab proteins are responsible for getting the vesicle to the correct location on a specific membrane. The SNARE proteins guide the docking of the vesicle onto the required organelle. vSNAREs release vesicles from the donor organelle and the tSNAREs guide vesicles to the receptor organelle.
Also see vesicle.
- ↑ Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P (2007:754) Molecular Biology of the Cell, 5th edition, New York: Garland Science
- ↑ Alberts B, Johnson A, Lewis J, Raff M, Roberts K and Walter P (2007:751) Molecular Biology of the Cell, 5th edition, New York: Garland Science
- ↑ Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2007:760) Molecular Biology of the Cell, 5th edition, New York, Garland Science