Viagra

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Viagra is the trademark name for the drug [[Sildenafil|sildenafil]], which was developed by the pharmaceutical company Pfizer. It is used to treat erectile dysfunction in males&nbsp;<ref>Francis, Sharron H., Corbin, Jackie D. (2005). Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction. Expert opinion on drug metabolism and toxicology. 1 (2), p283-293.</ref>. Initially it was widely used to relieve the symptoms of angina.<br>
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Viagra is the trademark name for the drug [[Sildenafil|sildenafil]], which was developed by the pharmaceutical company Pfizer. It is used to treat erectile dysfunction in males&nbsp;<ref>Francis, Sharron H., Corbin, Jackie D. (2005). Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction. Expert opinion on drug metabolism and toxicology. 1 (2), p283-293.</ref>. Initially it was widely used to relieve the symptoms of [[angina|angina]].<br>  
  
 
=== Mechanism of action  ===
 
=== Mechanism of action  ===
  
<span style="line-height: 1.5em">[[Acetylcholine|Acetylcholine]] is released by nerves in the walls of penile [[Blood_vessels|blood vessels ]]which causes [[Nitric oxide|nitric oxide]] (NO) to be released by [[Endothelial cells|endothelial cells]] in the vessel lining. NO binds to the enzyme [[Guanylyl cyclase|guanylyl cyclase]] in the smooth muscle cells of the blood vessel which catalyses the production of [[CGMP|cyclic GMP]] (cGMP) from [[GTP|GTP]]. The smooth muscle cells respond to this by relaxing which allows the blood vessel to dilate.</span>  
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<span style="line-height: 1.5em">[[Acetylcholine|Acetylcholine]] is released by nerves in the walls of penile [[Blood vessels|blood vessels which]] causes [[Nitric oxide|nitric oxide]] (NO) to be released by [[Endothelial cells|endothelial cells]] in the vessel lining. NO binds to the enzyme [[Guanylyl cyclase|guanylyl cyclase]] in the smooth muscle cells of the [[Blood_vessel|blood vessel]] which catalyses the production of [[CGMP|cyclic GMP]] (cGMP) from [[GTP|GTP]]. The smooth muscle cells respond to this by relaxing which allows the blood vessel to dilate.</span>  
  
[[CGMP|cGMP]] is quickly degraded by [[CGMP phosphodiesterase|cGMP phosphodiesterase]]. This enzyme hydrolyses cGMP to [[GMP|GMP]]. Viagra works to [[Competitive inhibitors|competitively inhibit]] cGMP phosphodiesterase so that [[Intracellular|intracellular]] levels of cGMP remain high, meaning penile blood vessels are dilated for a longer period of time<ref>Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p888-889.</ref>.<br>
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[[CGMP|cGMP]] is quickly degraded by [[CGMP phosphodiesterase|cGMP phosphodiesterase]]. This enzyme hydrolyses cGMP to [[GMP|GMP]]. Viagra works to [[Competitive inhibitors|competitively inhibit]] [[CGMP_phosphodiesterase|cGMP phosphodiesterase]] so that [[Intracellular|intracellular]] levels of cGMP remain high, meaning penile blood vessels are dilated for a longer period of time<ref>Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p888-889.</ref>.<br>  
  
 
=== References  ===
 
=== References  ===
  
 
<references />
 
<references />

Revision as of 20:06, 20 October 2016

Viagra is the trademark name for the drug sildenafil, which was developed by the pharmaceutical company Pfizer. It is used to treat erectile dysfunction in males [1]. Initially it was widely used to relieve the symptoms of angina.

Mechanism of action

Acetylcholine is released by nerves in the walls of penile blood vessels which causes nitric oxide (NO) to be released by endothelial cells in the vessel lining. NO binds to the enzyme guanylyl cyclase in the smooth muscle cells of the blood vessel which catalyses the production of cyclic GMP (cGMP) from GTP. The smooth muscle cells respond to this by relaxing which allows the blood vessel to dilate.

cGMP is quickly degraded by cGMP phosphodiesterase. This enzyme hydrolyses cGMP to GMP. Viagra works to competitively inhibit cGMP phosphodiesterase so that intracellular levels of cGMP remain high, meaning penile blood vessels are dilated for a longer period of time[2].

References

  1. Francis, Sharron H., Corbin, Jackie D. (2005). Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction. Expert opinion on drug metabolism and toxicology. 1 (2), p283-293.
  2. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p888-889.
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