Viagra

From The School of Biomedical Sciences Wiki
Revision as of 03:13, 4 December 2015 by 150063238 (Talk | contribs)
Jump to: navigation, search

Viagra is the trademark name for the drug sildenafil, which was developed by the pharmaceutical company Pfizer. It is used to treat erectile dysfunction in males [1]. Initially it was widely used to relieve the symptoms of angina.

Mechanism of action

Acetylcholine is released by nerves in the walls of penile blood vessels which causes nitric oxide (NO) to be released by endothelial cells in the vessel lining. NO binds to the enzyme guanylyl cyclase in the smooth muscle cells of the blood vessel which catalyses the production of cyclic GMP (cGMP) from GTP. The smooth muscle cells respond to this by relaxing which allows the blood vessel to dilate.

cGMP is quickly degraded by cGMP phosphodiesterase. This enzyme hydrolyses cGMP to GMP. Viagra works to competitively inhibit cGMP phosphodiesterase so that intracellular levels of cGMP remain high, meaning penile blood vessels are dilated for a longer period of time[2].

References

  1. Francis, Sharron H., Corbin, Jackie D. (2005). Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction. Expert opinion on drug metabolism and toxicology. 1 (2), p283-293.
  2. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p888-889.
Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox