Vibrio cholerae

Vibreo cholerae is a gram-negative bacterium which is both fermentative and oxidative in its metabolism. Its movement is enbled by a single polar flagellum ^[1].

There are hundreds of strains of V. cholerae, and only those which are infected by a mobile bacteriophage cause human disease such as the epidemic diarrheal disease, cholera^[2]. V. cholerae causes cholera by producing cholera toxins (CT) which consist of 2 subunits: A and B. The A subunit contains enzymatic activity and the B subunit binds to a cell-surface receptor called G_M1 on intestinal epithelial cells^[3].

References

1. ↑ www.textbookofbacteriology.net,2008,Vibreo cholerae and Asiatic cholera, Kenneth Todar
2. ↑ Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, Garland Science, Taylor and Francis Group. 2015; Page 1269-1270
3. ↑ Alberts B, Jonhson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, Garland Science, Taylor and Francis Group. 2015; Page 576