LECTURE TEN

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Synthetic Biology

© Jem Stach - Material intended solely for students enrolled @ Newcastle University - MSc Industrial and Commercial Biotechnology. jem.stach@newcastle.ac.uk

JSmailto:jem.stach@ncl.ac.uk?subject=BIO8041%20Query

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An area of science that is set to transform biotechnology and, likely, the world we live in. Aspects of drug production are given as examples.

Feng Q, et al. Production of artemisinin by genetically-modified microbes.

Biotechnol Lett. 2008 Apr;30(4):581-92. Epub 2007 Nov 16.

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Gibson DG et al. Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome.Science. 2008 Feb 29;319(5867):1215-20. doi: 10.1126/science.1151721. Epub 2008 Jan 24.

Hutchinson CA et al. Global transposon mutagenesis and a minimal Mycoplasma genome. Science. 1999 Dec 10;286(5447):2165-9.

Levskaya A et al. Synthetic biology: engineering Escherichia coli to see light. Nature. 2005 Nov 24;438(7067):441-2.

Martin VJ et al. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol. 2003 Jul;21(7):796-802. Epub 2003 Jun 1.

Weber W & Fussenegger M. The impact of synthetic biology on drug discovery. Drug Discov Today. 2009 Oct;14(19-20):956-63. doi: 10.1016/j.drudis.2009.06.010. Epub 2009 Jul 4.