LECTURE FIVE

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Post-genomics

© Jem Stach - Material intended solely for students enrolled @ Newcastle University - MSc Industrial and Commercial Biotechnology. jem.stach@newcastle.ac.uk

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Directed reading

Post-genomic approaches to natural product discovery: genome mining, heterologous expression, combinatorial biosynthesis, epigenetics and cell-free synthesis.

Laura S et al. Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol. 2005 Oct;1(5):265-9. Epub 2005 Sep 11.

Zazopoulos E et al. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol. 2003 Feb;21(2):187-90. Epub 2003 Jan 21.

Wenzel SC & Müller R. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol. 2005 Dec;16(6):594-606. Epub 2005 Oct 13.

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Cheng Q et al. Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol. 2007 Sep;3(9):557-8. Epub 2007 Aug 12.

Williams RB et al. Epigenetic remodeling of the fungal secondary metabolome. Org Biomol Chem. 2008 Jun 7;6(11):1895-7. doi: 10.1039/b804701d. Epub 2008 Apr 14.

Extra material associated with this lecture can be found in the Reading section