LECTURE NINE

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Polypharmacology

© Jem Stach - Material intended solely for students enrolled @ Newcastle University - MSc Industrial and Commercial Biotechnology. jem.stach@newcastle.ac.uk

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Directed reading

Lecture covers introduces the concept of polypharmacology and how we may exploit multiple-target compounds in the fight against antibiotic resistance

Pokrovskaya V, Baasov T. Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance. Expert Opin Drug Discov. 2010 Sep;5(9):883-902. doi: 10.1517/17460441.2010.508069. Epub 2010 Jul 21.

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Kinnings SL et al. The Mycobacterium tuberculosis drugome and its polypharmacological implications. PLoS Comput Biol. 2010 Nov 4;6(11):e1000976. doi: 10.1371/journal.pcbi.1000976.

Brötz-Oesterhelt H & Brunner NA. How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. doi: 10.1016/j.coph.2008.06.008. Epub 2008 Jul 30.