View source for PTBI

PTBI (IRS1-like) 

PTB ([[phosphotyrosine-binding domain|phosphotyrosine-binding domain]]) has a compact, 7-stranded beta-sandwich structure which is capped by a C-terminal helix, and is located near the N terminus<ref>Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.</ref>. 

Along with [[PH_domain|PH domains]], they facilitate interaction with the activated [[tyrosine-phosphorylated insulin receptor|tyrosine-phosphorylated insulin receptor]] in ISR-1<ref>Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.</ref>.<br> 

=== References  ===

<references /><br>