PTBI

From The School of Biomedical Sciences Wiki
Jump to: navigation, search

PTBI (IRS1-like)

PTB (phosphotyrosine-binding domain) has a compact, 7-stranded beta-sandwich structure which is capped by a C-terminal helix, and is located near the N terminus[1].

Along with PH domains, they facilitate interaction with the activated tyrosine-phosphorylated insulin receptor in ISR-1[2].

References

  1. Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.
  2. Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.

Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox