View source for Phosphatidylinositol 4,5-bisphosphate

Phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>) is a [[Phospholipid|phospholipid]] that covers a small percentage of the cell membrane. Interaction with [[Phospholipase C|phospholipase C]] results in the production of [[Inositol 1,4,5 trisphosphate|inositol 1,4,5-trisphosphate]] (IP<sub>3</sub>), which causes Ca<sup>2</sup><sup>+</sup> to be released from the endoplasmic reticulum, and [[Diacylglycerol|diacylglycerol]] (DAG). Ca<sup>2+</sup> and DAG activate [[Protein kinase C|protein kinase C]], which regulates other proteins by [[Phosphorylation|phosphorylation]]. This interaction is part of the [[Phosphoinositide pathway|phosphoinositide pathway]]. 

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