Phosphatidylinositol 4,5-bisphosphate

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Phosphatidylinositol 4,5-bisphosphate (PIP2) is a phospholipid that covers a small percentage of the cell membrane. Interaction with phospholipase C results in the production of inositol 1,4,5-trisphosphate (IP3), which causes Ca2+ to be released from the endoplasmic reticulum, and diacylglycerol (DAG). Ca2+ and DAG activate protein kinase C, which regulates other proteins by phosphorylation. This interaction is part of the phosphoinositide pathway.


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