SH2 domains: Difference between revisions
Jump to navigation
Jump to search
Created page with 'SH2 ('''S'''rc '''H'''omology '''2''') domains are phosphotyrosine residue binding domains which are heavily involved in signalling and cell communication. It has a number of imp…' |
(No difference)
|
Revision as of 12:51, 18 November 2010
SH2 (Src Homology 2) domains are phosphotyrosine residue binding domains which are heavily involved in signalling and cell communication. It has a number of important roles such as stabalising the inactive state of members of the Src family but it is also required by non-receptor tyrosine kinases in order to stabalize their active state. [1]
- ↑ P.Filippakopoulos, S.Muller, S.Knapp. SH2 domains: modulators of nonreceptor tyrosine kinase activity. Curr Opin Struct Biol. 2009 December; 19(6): 643–649.