SH2 (Src Homology 2) domains are phosphotyrosine residue binding domains which are heavily involved in signalling and cell communication. It has a number of important roles such as stabilising the inactive state of members of the Src family but it is also required by non-receptor tyrosine kinases in order to stabalize their active state .
- ↑ P.Filippakopoulos, S.Muller, S.Knapp. SH2 domains: modulators of nonreceptor tyrosine kinase activity. Curr Opin Struct Biol. 2009 December; 19(6): 643–649.