Histamine: Difference between revisions

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Histamine is a small [[Molecule|molecule]] secreted by [[Mast cells|mast cells]]. When specific [[Ligand|ligands]] bind to receptors on the mast cell surface,&nbsp;the mast cell is triggered and releases&nbsp;histamine. The released histamine enters nearby cells and causes [[Inflammation|inflammation]].<ref>http://www.nhs.uk/Conditions/Antihistamines/Pages/How-does-it-work.aspx</ref>&nbsp;Histamine causes the symptoms associated with [[Allergic reaction|allergic reactions]]&nbsp;such as sneezing and itching&nbsp;<ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. (2008), Molecular Biology of the Cell, 5th edition, New York: Garland Science.</ref>.&nbsp;  
Histamine is a small [[Molecule|molecule]] secreted by [[Mast cells|mast cells]]. When specific [[Ligand|ligands]] bind to receptors on the mast cell surface,&nbsp;the mast cell is triggered and releases&nbsp;histamine. The released histamine enters nearby cells and causes [[Inflammation|inflammation]]<ref>http://www.nhs.uk/Conditions/Antihistamines/Pages/How-does-it-work.aspx</ref>.&nbsp;Histamine causes the symptoms associated with [[Allergic reaction|allergic reactions]]&nbsp;such as sneezing and itching&nbsp;<ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. (2008), Molecular Biology of the Cell, 5th edition, New York: Garland Science.</ref>.&nbsp;  


[[G-protein_Coupled_Receptor|G-protein-coupled receptors ]]respond to histamine. All of the G-protein coupled receptors&nbsp;which respond to histamine are involved with producing the inflammatory response<ref>H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G.Henderson (2011)fckLRRang and Dale's pharmacology, 7th edition, page 211.</ref>.  
[[G-protein Coupled Receptor|G-protein-coupled receptors respond]] to histamine. All of the G-protein coupled receptors&nbsp;which respond to histamine are involved with producing the inflammatory response<ref>H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G.Henderson (2011)fckLRRang and Dale's pharmacology, 7th edition, page 211.</ref>.  


=== References  ===
=== References  ===

Revision as of 13:52, 19 October 2015

Histamine is a small molecule secreted by mast cells. When specific ligands bind to receptors on the mast cell surface, the mast cell is triggered and releases histamine. The released histamine enters nearby cells and causes inflammation[1]. Histamine causes the symptoms associated with allergic reactions such as sneezing and itching [2]. 

G-protein-coupled receptors respond to histamine. All of the G-protein coupled receptors which respond to histamine are involved with producing the inflammatory response[3].

References

  1. ↑ http://www.nhs.uk/Conditions/Antihistamines/Pages/How-does-it-work.aspx
  2. ↑ Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. (2008), Molecular Biology of the Cell, 5th edition, New York: Garland Science.
  3. ↑ H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G.Henderson (2011)fckLRRang and Dale's pharmacology, 7th edition, page 211.



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