Adrenegic receptor: Difference between revisions
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Adrenergic receptors respond to [[Adrenaline|adrenaline]] and [[Noradrenaline|noradrenaline]] and can be found in a variety of different tissues. | Adrenergic receptors respond to [[Adrenaline|adrenaline]] and [[Noradrenaline|noradrenaline]] and can be found in a variety of different tissues. | ||
Adrenergic receptors can be subdivided into two major classes: α- and β-adrenoreceptors. | Adrenergic receptors can be subdivided into two major classes: α- and β-adrenoreceptors. | ||
For α-adrenoreceptors, the potency and affinity is noradrenaline ≥ adrenaline >> isoprenaline. | For α-adrenoreceptors, the potency and affinity is noradrenaline ≥ adrenaline >> isoprenaline.<ref name="[1]">Whalen, K., Finkel, R. and Panavelil, T. (2015). Lippincott's Illustrated Reviews. Philadelphia, Pa.: Wolters Kluwer.</ref> | ||
For β-adrenoreceptors, the potency and affinity is isoprenaline > adrenaline > noradrenaline. | For β-adrenoreceptors, the potency and affinity is isoprenaline > adrenaline > noradrenaline.<ref name="[1]">Whalen, K., Finkel, R. and Panavelil, T. (2015). Lippincott's Illustrated Reviews. Philadelphia, Pa.: Wolters Kluwer.</ref> | ||
α-Adrenoreceptors are subdivided into two subgroups, α<sub>1</sub> and α<sub>2</sub> receptors. | α-Adrenoreceptors are subdivided into two subgroups, α<sub>1</sub> and α<sub>2</sub> receptors. | ||
β-Adrenoreceptors are subdivided into two subgroups, β<sub>1</sub> and β<sub>2</sub> receptors. | β-Adrenoreceptors are subdivided into two subgroups, β<sub>1</sub> and β<sub>2</sub> receptors. | ||
Adrenergic receptors are [[G-protein Coupled Receptor|G-protein coupled receptors]]. <ref>Gomparts,B.D (2009) 'signal transduction' (pp 38) Elsevier/academic press: Amsterdam.</ref> | Adrenergic receptors are [[G-protein Coupled Receptor|G-protein coupled receptors]]. <ref>Gomparts,B.D (2009) 'signal transduction' (pp 38) Elsevier/academic press: Amsterdam.</ref> | ||
Revision as of 07:24, 21 October 2015
Adrenergic receptors respond to adrenaline and noradrenaline and can be found in a variety of different tissues.
Adrenergic receptors can be subdivided into two major classes: α- and β-adrenoreceptors.
For α-adrenoreceptors, the potency and affinity is noradrenaline ≥ adrenaline >> isoprenaline.[1]
For β-adrenoreceptors, the potency and affinity is isoprenaline > adrenaline > noradrenaline.[1]
α-Adrenoreceptors are subdivided into two subgroups, α1 and α2 receptors.
β-Adrenoreceptors are subdivided into two subgroups, β1 and β2 receptors.
Adrenergic receptors are G-protein coupled receptors. [2]