Histamine: Difference between revisions
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Histamine is a small [[Molecule|molecule]] secreted by [[Mast cells|mast cells]]. When specific [[Ligand|ligands]] bind to receptors on the mast cell surface, the mast cell is triggered and releases histamine. The released histamine enters nearby cells and causes [[Inflammation|inflammation]]<ref>http://www.nhs.uk/Conditions/Antihistamines/Pages/How-does-it-work.aspx</ref>. Histamine causes the symptoms associated with [[Allergic reaction|allergic reactions]] such as sneezing and itching <ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. (2008), Molecular Biology of the Cell, 5th edition, New York: Garland Science.</ref>. Histamine is released during allergic reactions and the symptoms can be alleviated using | Histamine is a small [[Molecule|molecule]] secreted by [[Mast cells|mast cells]]. When specific [[Ligand|ligands]] bind to receptors on the mast cell surface, the mast cell is triggered and releases histamine. The released histamine enters nearby cells and causes [[Inflammation|inflammation]]<ref>http://www.nhs.uk/Conditions/Antihistamines/Pages/How-does-it-work.aspx</ref>. Histamine causes the symptoms associated with [[Allergic reaction|allergic reactions]] such as sneezing and itching <ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. (2008), Molecular Biology of the Cell, 5th edition, New York: Garland Science.</ref>. Histamine is released during allergic reactions and the symptoms can be alleviated using antihistamines. An antihistamine acts as an antagonist and can be taken either to prevent an allergic reaction or when experiencing an allergic reaction. For example, taking antihistamines in response to hayfever will act on the H2 receptors in the nose. | ||
[[G-protein Coupled Receptor|G-protein-coupled receptors respond]] to histamine. All of the G-protein coupled receptors which respond to histamine are involved with producing the inflammatory response<ref>H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G.Henderson (2011)fckLRRang and Dale's pharmacology, 7th edition, page 211.</ref>. | [[G-protein Coupled Receptor|G-protein-coupled receptors respond]] to histamine. All of the G-protein coupled receptors which respond to histamine are involved with producing the inflammatory response<ref>H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G.Henderson (2011)fckLRRang and Dale's pharmacology, 7th edition, page 211.</ref>. | ||
Latest revision as of 11:16, 22 October 2015
Histamine is a small molecule secreted by mast cells. When specific ligands bind to receptors on the mast cell surface, the mast cell is triggered and releases histamine. The released histamine enters nearby cells and causes inflammation[1]. Histamine causes the symptoms associated with allergic reactions such as sneezing and itching [2]. Histamine is released during allergic reactions and the symptoms can be alleviated using antihistamines. An antihistamine acts as an antagonist and can be taken either to prevent an allergic reaction or when experiencing an allergic reaction. For example, taking antihistamines in response to hayfever will act on the H2 receptors in the nose.
G-protein-coupled receptors respond to histamine. All of the G-protein coupled receptors which respond to histamine are involved with producing the inflammatory response[3].
References
- ↑ http://www.nhs.uk/Conditions/Antihistamines/Pages/How-does-it-work.aspx
- ↑ Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. (2008), Molecular Biology of the Cell, 5th edition, New York: Garland Science.
- ↑ H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G.Henderson (2011)fckLRRang and Dale's pharmacology, 7th edition, page 211.