Sensitization: Difference between revisions
Jump to navigation
Jump to search
Corrected referencing problems. |
No edit summary |
||
| Line 3: | Line 3: | ||
The first exposure to an [[Antigen|antigen]] will lead to sensitization which results in the development of allergic reaction for subsequent exposures<sup><sub>[2].</sub></sup><sub></sub> | The first exposure to an [[Antigen|antigen]] will lead to sensitization which results in the development of allergic reaction for subsequent exposures<sup><sub>[2].</sub></sup><sub></sub> | ||
During the first exposure to antigen, [[B lymphocytes|B lymphocytes]] that detect the [[Antigen|antigen]] will stimulate[[Immunoglobulin E|Immunoglobulin E]] (IgE) antibodies production<sup>[2].</sup> The 'binding of IgE antibodies to high affinity IgE receptors, FcεRI on the surface of mast cells' will lead to the formation of 'IgE binding cells'<ref>Murphy K, Travers P, Walport M, Janeway C. (2012) Janeway’s Immunobiology (571 – 581), 8th edition, New York: Garland Science.</ref>. | During the first exposure to antigen, [[B lymphocytes|B lymphocytes]] that detect the [[Antigen|antigen]] will stimulate[[Immunoglobulin E|Immunoglobulin E]] (IgE) antibodies production<sup>[2].</sup> The 'binding of [[IgE|IgE]] antibodies to high affinity IgE receptors, FcεRI on the surface of mast cells' will lead to the formation of 'IgE binding cells'<ref>Murphy K, Travers P, Walport M, Janeway C. (2012) Janeway’s Immunobiology (571 – 581), 8th edition, New York: Garland Science.</ref>. | ||
Through these steps, the individual has become sensitized to that [[Antigen|antigen]]<span style="font-size: 11px | Through these steps, the individual has become sensitized to that [[Antigen|antigen]]<span style="font-size: 11px"> <ref>Murphy K, Travers P, Walport M, Janeway C. (2012) Janeway’s Immunobiology (571 – 581), 8th edition, New York: Garland Science.</ref>.</span> The subsequent exposure to the same [[Allergen|allergens]] will trigger the activation of IgE binding cells (mast cells) to secrete the granule contents which cause the allergic symptoms<ref>Murphy K, Travers P, Walport M, Janeway C. (2012) Janeway’s Immunobiology (571 – 581), 8th edition, New York: Garland Science.</ref>. | ||
<sup></sup> | <sup></sup> | ||
=== <sup></sup>References === | === <sup></sup>References === | ||
<references /> | <references /> | ||
Revision as of 13:43, 18 October 2016
Sensitization is an "immunization" process caused by the "exposure to allergens that results in the development of hypersensitivity"[1].
The first exposure to an antigen will lead to sensitization which results in the development of allergic reaction for subsequent exposures[2].
During the first exposure to antigen, B lymphocytes that detect the antigen will stimulateImmunoglobulin E (IgE) antibodies production[2]. The 'binding of IgE antibodies to high affinity IgE receptors, FcεRI on the surface of mast cells' will lead to the formation of 'IgE binding cells'[2].
Through these steps, the individual has become sensitized to that antigen [3]. The subsequent exposure to the same allergens will trigger the activation of IgE binding cells (mast cells) to secrete the granule contents which cause the allergic symptoms[4].
References
- ↑ TheFreeDictionary.com. sensitization [Internet]. 2015 [cited 3 December 2015]. Available from: http://medical-dictionary.thefreedictionary.com/sensitization
- ↑ Murphy K, Travers P, Walport M, Janeway C. (2012) Janeway’s Immunobiology (571 – 581), 8th edition, New York: Garland Science.
- ↑ Murphy K, Travers P, Walport M, Janeway C. (2012) Janeway’s Immunobiology (571 – 581), 8th edition, New York: Garland Science.
- ↑ Murphy K, Travers P, Walport M, Janeway C. (2012) Janeway’s Immunobiology (571 – 581), 8th edition, New York: Garland Science.