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Immunoglobulin E (IgE) is the protein in antibodies associated with allergic responses and is produced when allergens enter the body, consequently resulting in an allergic reaction [1].

IgE has a molecular weight of 200 kDa, 5 domains and a ε chain.

IgE is found in very low concentrations in serum and plays an important role in imflammation due to its high affinity to binding to FcRs (Fc receptors) on mast cells which casues mast cell degranulation.

Plasma cells in thelymph nodes are responsible for the production of IgE [2].

Although IgE is produced in the plasma cells, they are firmly bound to their FcεRI receptors found on the cell surface of mast-cells.

On the other hand, these receptors that are unique to IgE are not just found on the mast-cells, they can also be expressed by basophils and activated eosinophils [3].


  1. Silverthorn, Dee Unglaub., Johnson, Bruce R., Ober, William C., Garrison, Claire W., Silverthorn, Andrew C.(2009)Human Physiology: An integrated approach, 5th edition, New York: Pearson International. p795
  2. http://www.ncbi.nlm.nih.gov/books/NBK27117/
  3. http://www.ncbi.nlm.nih.gov/books/NBK27117/

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