Glucokinase: Difference between revisions
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Glucokinase is an enzyme that phosphorylates glucose to become glucose-6-phosphate. It is an isozyme of hexokinase (hexokinase IV) that is present in hepatocytes. Compared to the other forms of hexokinase, glucokinase has a low affinity for glucose. This means that when glucose levels in the body are low, glucose isn't phosphorylated to become glucose-6-phosphate, and it goes to other tissues that have a greater need for the glucose. Furthermore, glucokinase is not inhibited by the product glucose-6-phosphate. This allows the enzyme to continually phosphorylate glucose, even when the concentration of glucose-6-phosphate is very high<ref>Lehninger, A. L. Nelson, D. L. Cox, M. M. (2000) Principles of Biochemistry, 6th edition, New York: Worth Publishers. Chapter 15, page 578.</ref>. | Glucokinase is an [[enzyme|enzyme]] that [[Phosphorylation|phosphorylates]] [[glucose|glucose]] to become [[Glucose-6-phosphate|glucose-6-phosphate]]. It is an [[isozyme|isozyme]] of [[hexokinase|hexokinase]] ([[hexokinase IV|hexokinase IV]]) that is present in [[hepatocytes|hepatocytes]]. Compared to the other forms of hexokinase, glucokinase has a low affinity for glucose. This means that when glucose levels in the body are low, glucose isn't phosphorylated to become glucose-6-phosphate, and it goes to other tissues that have a greater need for the glucose. Furthermore, glucokinase is not inhibited by the product glucose-6-phosphate. This allows the enzyme to continually phosphorylate glucose, even when the concentration of glucose-6-phosphate is very high<ref>Lehninger, A. L. Nelson, D. L. Cox, M. M. (2000) Principles of Biochemistry, 6th edition, New York: Worth Publishers. Chapter 15, page 578.</ref>. <span> | ||
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=== <span>References </span> === | === <span>References </span> === | ||
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Revision as of 08:15, 21 October 2016
Glucokinase is an enzyme that phosphorylates glucose to become glucose-6-phosphate. It is an isozyme of hexokinase (hexokinase IV) that is present in hepatocytes. Compared to the other forms of hexokinase, glucokinase has a low affinity for glucose. This means that when glucose levels in the body are low, glucose isn't phosphorylated to become glucose-6-phosphate, and it goes to other tissues that have a greater need for the glucose. Furthermore, glucokinase is not inhibited by the product glucose-6-phosphate. This allows the enzyme to continually phosphorylate glucose, even when the concentration of glucose-6-phosphate is very high[1].
References
- ↑ Lehninger, A. L. Nelson, D. L. Cox, M. M. (2000) Principles of Biochemistry, 6th edition, New York: Worth Publishers. Chapter 15, page 578.