Deletion mutation: Difference between revisions
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A deletion is a type of [[Mutation|mutation]] that occurs when a single [[Nucleotide|nucleotide]], or sequence of nucleotides has been ommitted from the [[DNA|DNA]] sequence. The effect of this is a [[Frameshift Mutation|frameshift mutation]], which causes radical changes to the [[Protein|protein]] that is translated and it invariably leads to a truncated protein. This is because the [[Amino Acids|amino acids]] used to form proteins are coded for by a sequence of three non-overlapping bases in the DNA sequence, therefore if one or more of the bases is deleted, every [[Triplet code|triplet code]] following this will have shifted and will generate a completely different amino acid. The resulting protein will be inactive as it will no longer be the correct shape for its original function. <ref>Hartl DL, Ruvolo M. Genetics: Analysis of genes and genomes. Jones | A deletion is a type of [[Mutation|mutation]] that occurs when a single [[Nucleotide|nucleotide]], or sequence of nucleotides has been ommitted from the [[DNA|DNA]] sequence. The effect of this is a [[Frameshift Mutation|frameshift mutation]], which causes radical changes to the [[Protein|protein]] that is translated and it invariably leads to a truncated protein. This is because the [[Amino Acids|amino acids]] used to form proteins are coded for by a sequence of three non-overlapping bases in the DNA sequence, therefore if one or more of the bases is deleted, every [[Triplet code|triplet code]] following this will have shifted and will generate a completely different amino acid. The resulting protein will be inactive as it will no longer be the correct shape for its original function. <ref>Hartl DL, Ruvolo M. Genetics: Analysis of genes and genomes. Jones and Bartlett Learning; 8 edition (August 19, 2011)</ref> | ||
=== References === | === References === | ||
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Latest revision as of 15:58, 4 December 2016
A deletion is a type of mutation that occurs when a single nucleotide, or sequence of nucleotides has been ommitted from the DNA sequence. The effect of this is a frameshift mutation, which causes radical changes to the protein that is translated and it invariably leads to a truncated protein. This is because the amino acids used to form proteins are coded for by a sequence of three non-overlapping bases in the DNA sequence, therefore if one or more of the bases is deleted, every triplet code following this will have shifted and will generate a completely different amino acid. The resulting protein will be inactive as it will no longer be the correct shape for its original function. [1]
References
- ↑ Hartl DL, Ruvolo M. Genetics: Analysis of genes and genomes. Jones and Bartlett Learning; 8 edition (August 19, 2011)