Haemolytic anaemia: Difference between revisions
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Haemolytic anaemia is a condition where [[Haemolysis|haemolytic]] levels exceed [[Erythrocyte|erythrocyte]] production in the [[Bone marrow|bone marrow]], thereby resulting in | Haemolytic anaemia is a condition where [[Haemolysis|haemolytic]] levels exceed [[Erythrocyte|erythrocyte]] production in the [[Bone marrow|bone marrow]], thereby resulting in anaemia<ref>Valent P, Lechner K. Diagnosis and treatment of autoimmune haemolytic anaemias in adults: a clinical review. Wiener klinische Wochenschrift. 2008 Mar 1;120(5-6):136-51.</ref>. | ||
=== Causes === | === Causes === | ||
| Line 7: | Line 7: | ||
Intrinsic: | Intrinsic: | ||
#Defects in erythrocyte | #Defects in erythrocyte membranes<ref>Gallagher PG. Abnormalities of the erythrocyte membrane. Pediatric Clinics of North America. 2013 Dec;60(6):1349.</ref> | ||
#Defects in | #Defects in haemoglobin<ref>Forget BG, Bunn HF. Classification of the disorders of hemoglobin. Cold Spring Harbor perspectives in medicine. 2013 Feb 1;3(2):a011684.</ref> | ||
#Defects in erythrocyte metabolic pathways<ref>Jacobasch G, Rapoport SM. Hemolytic anemias due to erythrocyte enzyme deficiencies. Molecular aspects of medicine. 1996 Apr 1;17(2):143-70.</ref> | #Defects in erythrocyte metabolic pathways<ref>Jacobasch G, Rapoport SM. Hemolytic anemias due to erythrocyte enzyme deficiencies. Molecular aspects of medicine. 1996 Apr 1;17(2):143-70.</ref> | ||
Revision as of 15:04, 28 October 2017
Haemolytic anaemia is a condition where haemolytic levels exceed erythrocyte production in the bone marrow, thereby resulting in anaemia[1].
Causes
There are intrinsic and extrinsic causes that may result in haemolytic anaemia:
Intrinsic:
- Defects in erythrocyte membranes[2]
- Defects in haemoglobin[3]
- Defects in erythrocyte metabolic pathways[4]
Extrinsic:
- Immune-mediated causes such as autoimmune haemolytic anaemia[5]
- Lead poisoning[6]
- Runners' macrocytosis (enlargement of red blood cells with near-constant hemoglobin concentration)[7]
References
- ↑ Valent P, Lechner K. Diagnosis and treatment of autoimmune haemolytic anaemias in adults: a clinical review. Wiener klinische Wochenschrift. 2008 Mar 1;120(5-6):136-51.
- ↑ Gallagher PG. Abnormalities of the erythrocyte membrane. Pediatric Clinics of North America. 2013 Dec;60(6):1349.
- ↑ Forget BG, Bunn HF. Classification of the disorders of hemoglobin. Cold Spring Harbor perspectives in medicine. 2013 Feb 1;3(2):a011684.
- ↑ Jacobasch G, Rapoport SM. Hemolytic anemias due to erythrocyte enzyme deficiencies. Molecular aspects of medicine. 1996 Apr 1;17(2):143-70.
- ↑ Gehrs BC, Friedberg RC. Autoimmune hemolytic anemia. American journal of hematology. 2002 Apr 1;69(4):258-71.
- ↑ Valentine WN, Paglia DE, Fink K, Madokoro G. Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines. Journal of Clinical Investigation. 1976 Oct;58(4):926.
- ↑ Eichner ER. Runner's macrocytosis: a clue to footstrike hemolysis. Runner's anemia as a benefit versus runner's hemolysis as a detriment. The American journal of medicine. 1985 Feb 1;78(2):321-5.