Cyclic GMP: Difference between revisions
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In response to extracellular signals, [[Guanylyl cyclase|guanylyl cyclase]] | In response to extracellular signals, [[Guanylyl cyclase|guanylyl cyclase]] converts the [[Nucleotide|nucleotide]] [[GTP|GTP]] to cyclic GMP. It is an intracellular signalling molecule. For example, in the [[Smooth muscle|smooth muscle]] of [[Blood vessels|blood vessels]], [[Nitric Oxide|NO]] binds to the [[Iron|iron]] in the active site of [[Guanylyl cyclase|guanlyl cyclase]], activating the [[Enzyme|enzyme]] and leading to the production of cyclic GMP. In response to this, the blood vessel dilates. Cyclic GMP is broken down to GMP by [[CGMP phosphodiesterase|cyclic GMP phosphodiesterase]]<ref>Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P. (2008) Molecular Biology of the Cell (5th Edition) New York: Garland Science. P888-889</ref>. | ||
Cyclic GMP (cGMP) is a nucleotide which is synthesised from GTP using the [[Enzyme|enzyme]] [[Guanylyl cyclase|guanylyl cyclase]]. It is broken down by cyclic GMP [[Phosphodiesterase|phosphodiesterase]]. It is very important in controlling visual transduction responses. It is especially important for keeping cyclic GMP gated [[Cation channels|cation channels]] open in the dark, which are found in the [[Plasma membrane|plasma membrane]] surrounding the outer segments of a rod | Cyclic GMP (cGMP) is a nucleotide which is synthesised from GTP using the [[Enzyme|enzyme]] [[Guanylyl cyclase|guanylyl cyclase]]. It is broken down by cyclic GMP [[Phosphodiesterase|phosphodiesterase]]. It is very important in controlling visual transduction responses. It is especially important for keeping cyclic GMP gated [[Cation channels|cation channels]] open in the dark, which are found in the [[Plasma membrane|plasma membrane]] surrounding the outer segments of a rod<ref>Alberts et al. Molecular Biology of the Cell 5th Ed (917)</ref>. | ||
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Latest revision as of 16:32, 29 November 2017
In response to extracellular signals, guanylyl cyclase converts the nucleotide GTP to cyclic GMP. It is an intracellular signalling molecule. For example, in the smooth muscle of blood vessels, NO binds to the iron in the active site of guanlyl cyclase, activating the enzyme and leading to the production of cyclic GMP. In response to this, the blood vessel dilates. Cyclic GMP is broken down to GMP by cyclic GMP phosphodiesterase[1].
Cyclic GMP (cGMP) is a nucleotide which is synthesised from GTP using the enzyme guanylyl cyclase. It is broken down by cyclic GMP phosphodiesterase. It is very important in controlling visual transduction responses. It is especially important for keeping cyclic GMP gated cation channels open in the dark, which are found in the plasma membrane surrounding the outer segments of a rod[2].