Gene knockout: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Add some more information |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
A gene knockout is a [[Deletion mutation|deletion mutation]] where part of a [[Gene|gene]] is missing, making the [[Wild - type|wildtype]] nonfunctional. Gene knockout is a technique often used when producing [[Transgenic Organism|transgenic]] animals to study the function of specific [[Gene|genes]], as loss of a certian funtion in the [[Transgenic Organism|transgenic]] animal can give important information about the function of the [[Gene|gene]] that has been knocked out. Gene knockout is a potent and irreversible means to inactivate a [[Genes|gene]]<ref>Transgenic Animal Technology (Third Edition). A Laboratory Handbook. Carl A. Pinkert</ref>. Gene knockout is also often used to produce [[Transgenic mice|transgenic mice]] with knockouts of [[Homologous|homologs]] of [[Gene|genes]] associated with human disease that act as models for humans diseases<ref>D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.</ref>. | |||
=== References === | |||
<references /> | |||
Latest revision as of 17:54, 2 December 2017
A gene knockout is a deletion mutation where part of a gene is missing, making the wildtype nonfunctional. Gene knockout is a technique often used when producing transgenic animals to study the function of specific genes, as loss of a certian funtion in the transgenic animal can give important information about the function of the gene that has been knocked out. Gene knockout is a potent and irreversible means to inactivate a gene[1]. Gene knockout is also often used to produce transgenic mice with knockouts of homologs of genes associated with human disease that act as models for humans diseases[2].