Gene knockout

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A gene knockout is a deletion mutation where part of a gene is missing, making the wildtype nonfunctional. Gene knockout is a technique often used when producing transgenic animals to study the function of specific genes, as loss of a certian funtion in the transgenic animal can give important information about the function of the gene that has been knocked out. Gene knockout is a potent and irreversible means to inactivate a gene[1]. Gene knockout is also often used to produce transgenic mice with knockouts of homologs of genes associated with human disease that act as models for humans diseases[2].

References

  1. Transgenic Animal Technology (Third Edition). A Laboratory Handbook. Carl A. Pinkert
  2. D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.
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