Grb-2: Difference between revisions
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Created page with 'Grb-2 stands for growth factor receptor bound protein 2<ref name="Wikipedia">growth factor receptor protein</ref>, is an adaptor protein fuond in humans. This adaptor protein is …' |
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Grb-2 stands for growth factor receptor bound protein 2<ref name="Wikipedia">growth factor receptor protein</ref>, is an adaptor protein | Grb-2 stands for growth factor receptor bound protein 2 <ref name="Wikipedia">growth factor receptor protein</ref>, is an adaptor protein found in humans. This adaptor [[protein|protein]] is also present in the [[Ras|Ras]] signalling pathway. What it does is that it bind to the receptor tyrosine kinase (Grb2 has an [[SH2_domains|SH2 domain]]), which then binds the [[GEF|GEF]], which causes the release of [[GDP|GDP]] by [[Ras|Ras]] ([[Ras|Ras]] is a [[Monomeric G-protein|monomeric G-protein]]), which then takes up [[GTP|GTP]], causing activation, which in turn delivers the signal on to other [[Kinase|kinases]].<br> | ||
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Revision as of 16:19, 11 January 2011
Grb-2 stands for growth factor receptor bound protein 2 [1], is an adaptor protein found in humans. This adaptor protein is also present in the Ras signalling pathway. What it does is that it bind to the receptor tyrosine kinase (Grb2 has an SH2 domain), which then binds the GEF, which causes the release of GDP by Ras (Ras is a monomeric G-protein), which then takes up GTP, causing activation, which in turn delivers the signal on to other kinases.
References
- ↑ growth factor receptor protein