Paracellin-1: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
Paracellin-1, also known as Claudin 16, is one of the transmembrane linker proteins of tight junctions and is part of the Claudin family. This protein is found in the thick ascending limb of the [[Loop of Henle|Loop of Henle]] in the Renal Tubule. | Paracellin-1, also known as Claudin 16, is one of the [[Transmembrane|transmembrane]] linker [[Proteins|proteins]] of [[Tight junctions|tight junctions]] and is part of the Claudin family. This [[Proteins|protein]] is found in the thick ascending limb of the [[Loop of Henle|Loop of Henle]] in the [[Renal Tubule|Renal Tubule]] <ref>Ikari A, Ito M, Okude C, Sawada H, Harada H, Degawa M, Sakai H, Takahashi T, Sugatani J, Miwa M. (2008) Claudin-16 is directly phosphorylated by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway. Journal of cellular physiology. 214(1):221-9.</ref>. | ||
'''<u>Mutation of Paracellin-1</u>''' | '''<u>Mutation of Paracellin-1</u>''' | ||
Recessive mutations in Paracellin-1 leads to hypomagnesaemia in humans. Magnesium movement in the thick ascending limb is controlled by a paracellular pathway which is altered by mutations in Paracellin-1 which therefore leads to less magnesium being reabsorbed. Calcium movement is also disturbed causing hypercalciuria and nephrocalcinosis. | [[Recessive_gene|Recessive]] mutations in Paracellin-1 leads to [[Hypomagnesaemia|hypomagnesaemia]] in humans. [[Magnesium|Magnesium]] movement in the thick ascending limb is controlled by a paracellular pathway which is altered by mutations in Paracellin-1 which therefore leads to less [[Magnesium|magnesium]] being reabsorbed. [[Calcium|Calcium]] movement is also disturbed causing [[Hypercalciuria|hypercalciuria]] and [[Nephrocalcinosis|nephrocalcinosis]] <ref>Hampson G, Konrad MA, Scoble J. (2008) Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): compound heterozygous mutation in the claudin 16 (CLDN16) gene. BMC nephrology Journal. 9:12</ref>. | ||
=== References === | |||
<references /><br> | |||
<br> | |||
<br> | <br> | ||
Latest revision as of 07:16, 24 August 2011
Paracellin-1, also known as Claudin 16, is one of the transmembrane linker proteins of tight junctions and is part of the Claudin family. This protein is found in the thick ascending limb of the Loop of Henle in the Renal Tubule [1].
Mutation of Paracellin-1
Recessive mutations in Paracellin-1 leads to hypomagnesaemia in humans. Magnesium movement in the thick ascending limb is controlled by a paracellular pathway which is altered by mutations in Paracellin-1 which therefore leads to less magnesium being reabsorbed. Calcium movement is also disturbed causing hypercalciuria and nephrocalcinosis [2].
References
- ↑ Ikari A, Ito M, Okude C, Sawada H, Harada H, Degawa M, Sakai H, Takahashi T, Sugatani J, Miwa M. (2008) Claudin-16 is directly phosphorylated by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway. Journal of cellular physiology. 214(1):221-9.
- ↑ Hampson G, Konrad MA, Scoble J. (2008) Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): compound heterozygous mutation in the claudin 16 (CLDN16) gene. BMC nephrology Journal. 9:12