Looking at the disease on a cellular level
Transcellular transport creates an electrical gradient (where the basolateral membrane is negatively charged) for Mg2+ absorption via the paracellular pathway in the thick ascending Loop of Henle. This then causes magnesiun ions to be excreted in the urine.
Note that hypomagnesaemia is not the same as magnesium deficiency, as one can be present without the other .
- Electrolyte disturbances
- Muscle Weakness
- Neuromuscular Dysfunction
- Cardiac Arrythmias
- Kidney Stones
- Renal Failure