Multidrug resistance: Difference between revisions
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Multidrug resistance is a condition where a cell is resisted to a large-variety of drugs. This condition is due to the increased expression of [[ABC Superfamily|ABC Superfamily]] transporter and is making chemotherapy for cancer difficult. | Multidrug resistance is a condition where a cell is resisted to a large-variety of drugs. This condition is due to the increased expression of [[ABC Superfamily|ABC Superfamily]] transporter and is making [[chemotherapy|chemotherapy]] for [[cancer|cancer]] difficult. | ||
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Latest revision as of 10:58, 7 November 2011
Multidrug resistance is a condition where a cell is resisted to a large-variety of drugs. This condition is due to the increased expression of ABC Superfamily transporter and is making chemotherapy for cancer difficult.
ABC Superfamily transporter that are thought to be associated with multidrug resistance:
| Protein name (offical name) |
Family |
Description |
| P-glycoprotein (ABCB1) |
B Family |
A protein that transport wide range of substances. Expression of this protein protect main organs from toxic moleclues and involve in steroid secretion. |
| Multidrug-resistance-associated protein 2 (ABCC2) |
C Family |
Transport molecules across the membrane. |
| Mitoxantrone-resistance protein (ABCG2) | G Family |
Transport xenobiotic. |