Multidrug resistance

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Multidrug resistance is a condition where a cell is resisted to a large-variety of drugs. This condition is due to the increased expression of ABC Superfamily transporter and is making chemotherapy for cancer difficult.


ABC Superfamily transporter that are thought to be associated with multidrug resistance:

Protein name (offical name)
Family    
Description
P-glycoprotein (ABCB1)
B Family
A protein that transport wide range of substances. Expression of this protein protect main organs from toxic moleclues and involve in steroid secretion.
Multidrug-resistance-associated protein 2 (ABCC2)
C Family
Transport molecules across the membrane.
Mitoxantrone-resistance protein (ABCG2) G Family
Transport xenobiotic.


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